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Microbiology

Microbiology

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Pseudomonas aeruginosa: The Opportunistic Pathogen That Thrives Where Medicine Is Weakest

Pseudomonas aeruginosa is a gram-negative, rod-shaped bacterium that rarely sickens healthy people but becomes a dangerous opportunistic pathogen in those with weakened defenses — burn victims, cystic fibrosis patients, and hospitalized or immunocompromised patients. A member of the ESKAPE group of drug-resistant microbes, it combines intrinsic multidrug resistance, protective biofilms, and a deep toolkit of virulence factors (including the blue pigment pyocyanin), which together make its chronic infections notoriously hard to cure.

Staphylococcus aureus: Skin Commensal, Hospital Killer, and the Toxin Cooking Can't Destroy

Staphylococcus aureus is a gram-positive coccus that lives harmlessly on the skin and in the nose of roughly a third of people, yet turns opportunistic pathogen to cause skin abscesses, sepsis, pneumonia, and toxic shock. Its rapid evolution of antibiotic resistance produced MRSA, and one strain trait makes it a distinct food-safety hazard: it secretes heat-stable enterotoxins that survive cooking even after the bacteria are killed.

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